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IIT Kanpur scientists have unlocked the mystery behind the C5aR2 immune receptor's unique function. Using advanced cryo-EM, they discovered a structural difference in its inner part, explaining its distinct signaling pathway compared to its counterpart, C5aR1. This breakthrough led to the creation of a new molecule, R8Y, which selectively targets C5aR2, paving the way for more precise drug development and a deeper understanding of immune responses. 
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